Fresh analysis reveals that people who discontinue popular weight-loss injections like semaglutide or tirzepatide tend to recover shed pounds at a significantly accelerated pace than those who stop traditional diet and exercise programs.
Research printed in a prominent medical journal points out that while obese people can lose substantial amounts of their body weight while using the jabs, the mass returns at an average rate of nearly a kilo each month after stopping.
"Users buying these treatments need to be informed of the potential of fast weight regain when the medication is stopped," stated lead investigator Dr. Susan Jebb.
Such speed of recovery suggests a return to pre-treatment weight within about 18 months.
Weighing Approaches
The research, which reviewed 37 of studies involving over 9,000 of patients, compared the results of these new drugs with other pills.
Researchers emphasize that people who lose weight through diet and exercise usually experience a more gradual weight regain—approximately 0.1 kg a month—post-intervention.
Understanding the Rapid Rebound
Doctors suggest the mode of action of the injections explains the amplified weight return.
These medications mimic a body's own chemical called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 levels far above than normal could lead to the body to generate a reduced amount of its endogenous GLP-1, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication means hunger is no longer kept in check, making binge eating much more probable."
An Ongoing Issue?
Health authorities advise the injections for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians say that, considering the high risk of relapse, the treatment should be considered long-term.
This view is supported by pharmaceutical companies, who say that the results "emphasize the chronic nature of excess weight," similar to managing diseases like hypertension.
Patient Experiences
People who have come off the medication report a sudden return of cravings.
"It felt as if something flipping and you're instantly starving," recalled a patient.
The struggle is exacerbated if individuals have not adopted sustainable dietary or behavioural modifications during treatment.
Growing Adoption
Recent estimates show that a significant number of people in the UK have tried these injections in the past year, with desire being substantial.
- Use is more common among females than males.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
In conclusion, researchers stress that while the jabs are effective tools for shedding pounds, they are not a permanent fix and lasting health benefits relies on combined lifestyle management.
